{"title":"Melatonin For Dogs","description":"Lignans for Life melatonin supplements for dogs can help with hyperactivity, restlessness, separation issues, and other stressful situations. For anxious or overly excitable canines, melatonin can work wonders. Check out our selection of melatonin for dogs below.","products":[{"product_id":"melatonin-1mg-180-capsules","title":"K9 Select 1mg Melatonin","description":"\u003ch1\u003eK9 Select Melatonin 1 mg For Dogs.\u003c\/h1\u003e\n\u003cp\u003e\u003cb\u003e\u003c\/b\u003e180 capsules, 180 1 mg. servings. Each bottle contains 180 capsules of 1 mg human-grade \u003ca href=\"https:\/\/www.lignans.net\/product-category\/dogs\/melatonin-dogs\/\"\u003emelatonin for dogs\u003c\/a\u003e. Our K9 Select brand melatonin supplement for dogs is carefully formulated to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePromote a natural sleep-wake cycle *\u003c\/li\u003e\n\u003cli\u003eProvide natural hormone support *\u003c\/li\u003e\n\u003cli\u003ePromote relaxation, calm and comfort *\u003c\/li\u003e\n\u003cli\u003eSupport overall health – promote normal thirst and urination *\u003c\/li\u003e\n\u003cli\u003eDaily use supports normal skin and coat health *\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow Melatonin Works\u003c\/h3\u003e\n\u003cp\u003eIn humans, dogs, and other animals, melatonin plays an important role in the regulation of the sleep-wake cycle. Melatonin is naturally produced by the body in the pineal system. In healthy animals, peak production of melatonin naturally occurs after sunset. Melatonin signals to the body both time of day and season (length of night). However natural production decreases as we and our pets age. This is one reason older people and pets find it difficult to get quality sleep or to sleep for as many hours as when we were younger.\u003c\/p\u003e\n\u003ch3\u003eMelatonin Health Benefits\u003c\/h3\u003e\n\u003cp\u003eSupplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and anxiety. * Melatonin decreases sex hormone secretion, modulates aromatase activity, and inhibits cortisol production. It has also been shown in some animal models to inhibit androgen production and ovarian activity.\u003ca href=\"https:\/\/avmajournals.avma.org\/doi\/abs\/10.2460\/ajvr.72.5.675\" rel=\"noopener noreferrer\" target=\"_blank\"\u003e Further reading here. \u003c\/a\u003eMelatonin’s anti-estrogenic properties have been extensively studied. Melatonin acts in several ways to limit estrogen production and\/or activities, including by interfering with estrogen receptor activities, down regulating estrogen expression during transcription, reducing estrogen receptor sensitivity, and inhibiting the expression of key enzymes (like aromatase) involved in estrogen production. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0301008208000348\" rel=\"noopener noreferrer\" target=\"_blank\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.omicsonline.org\/open-access\/melatonininduced-oncostasis-mechanisms-and-clinical-relevance-2329-6771-S1-006.php?aid=68975\" rel=\"noopener noreferrer\" target=\"_blank\"\u003ehere.\u003c\/a\u003e In addition, melatonin has been shown not only to inhibit cortisol itself, but also the chemical (ACTH) that signals the adrenal gland to produce cortisol. \u003ca href=\"https:\/\/academic.oup.com\/jcem\/article\/88\/1\/450\/2846096\" rel=\"noopener noreferrer\" target=\"_blank\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21332028\" rel=\"noopener noreferrer\" target=\"_blank\"\u003ehere. \u003c\/a\u003e* Studies have shown that melatonin can reduce symptoms of stress in canines, including refusal to eat, excessive pacing or panting, as well as whimpering and licking. Melatonin may also help reduce aggressive behavior in dogs. Because the body responds to stress by producing additional cortisol, the reduction in stress, anxiety and aggression that results from melatonin supplementation may have a secondary effect (beyond the direct effects noted above) of lowering cortisol levels. * \u003cb\u003eNote:\u003c\/b\u003e Always consult your physician or veterinarian before taking melatonin for yourself or your dog. For treatment of dogs, you should not use a rapid release melatonin or a timed-release melatonin. Use only regular melatonin. All of our melatonin products fit these criteria. \u003ca href=\"https:\/\/www.veterinaryplace.com\/dog-medicine\/melatonin\/\" rel=\"noopener noreferrer\" target=\"_blank\"\u003eSee the recommended treatment protocols here.\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003eDirections for Dogs\u003c\/h3\u003e\n\u003cp\u003eThe University of Tennessee College of Veterinary Medicine recommends, and the late Dr. Jack Oliver, DVM, former Chairman of UofT's Veterinary Endocrinology Department, recommended:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e3 mg of melatonin (3 capsules) every 12 hours for dogs under 30 lbs.\u003c\/li\u003e\n\u003cli\u003e6 mg of melatonin (6 capsules) every 12 hours for dogs over 30 lbs.\u003c\/li\u003e\n\u003cli\u003e1 mg of melatonin (1 capsule) every 12 hours may be recommended for dogs 10 lbs. or less, or for those who want to give their dogs very low doses of melatonin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.lignans.net\/melatonin-dosage-for-dogs.html\" rel=\"noopener noreferrer\" target=\"_blank\"\u003eRecommended dosages for dogs.\u003c\/a\u003e Melatonin may also help anxious dogs by reducing stress hormone levels. * For this use, give 1 serving 30 minutes before stressful event.\u003c\/p\u003e","brand":"Lignans","offers":[{"title":"Default Title","offer_id":45554611159322,"sku":"20002","price":14.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/0362\/8570\/files\/1mg-GalleryImage1.jpg?v=1729436236"},{"product_id":"k9-select-chewable-1-mg-melatonin-for-dogs-beef-flavor-180-tabs","title":"1 mg Beef Melatonin K9 Select","description":"\u003ch1\u003eK9 Select Beef Flavored 1MG Melatonin\u003c\/h1\u003e\n\u003cp\u003e\u003cb\u003e\u003c\/b\u003e180 1 mg. servings. Now in a tasty beef liver-flavored 1 mg tablet! Our K9 Select brand melatonin supplements for dogs are tasty chewable tablets, carefully formulated to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePromote a natural sleep-wake cycle *\u003c\/li\u003e\n\u003cli\u003eProvide natural hormone support *\u003c\/li\u003e\n\u003cli\u003ePromote relaxation, calm and comfort *\u003c\/li\u003e\n\u003cli\u003eSupport overall health – promote normal thirst and urination *\u003c\/li\u003e\n\u003cli\u003eDaily use promotes normal skin and coat health *\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow Melatonin Works\u003c\/h3\u003e\n\u003cp\u003eIn humans, dogs, and other animals, melatonin plays an important role in the regulation of the sleep-wake cycle. Melatonin is naturally produced by the body in the pineal system. In healthy animals, peak production of melatonin naturally occurs after sunset. Melatonin signals to the body both time of day and season (length of night). However natural production decreases as we and our pets age. This is one reason older people and pets find it difficult to get quality sleep or to sleep for as many hours as when we were younger.\u003c\/p\u003e\n\u003ch3\u003eMelatonin Health Benefits\u003c\/h3\u003e\n\u003cp\u003eSupplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and anxiety. * Melatonin decreases sex hormone secretion, modulates aromatase activity, and inhibits cortisol production. It has also been shown in some animal models to inhibit androgen production and ovarian activity.\u003ca href=\"https:\/\/avmajournals.avma.org\/doi\/abs\/10.2460\/ajvr.72.5.675\" target=\"_blank\"\u003e Further reading here. \u003c\/a\u003eMelatonin’s anti-estrogenic properties have been extensively studied. Melatonin acts in several ways to limit estrogen production and\/or activities, including by interfering with estrogen receptor activities, down regulating estrogen expression during transcription, reducing estrogen receptor sensitivity, and inhibiting the expression of key enzymes (like aromatase) involved in estrogen production. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0301008208000348\" target=\"_blank\" rel=\"noopener\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.omicsonline.org\/open-access\/melatonininduced-oncostasis-mechanisms-and-clinical-relevance-2329-6771-S1-006.php?aid=68975\" target=\"_blank\"\u003ehere.\u003c\/a\u003e In addition, melatonin has been shown not only to inhibit cortisol itself, but also the chemical (ACTH) that signals the adrenal gland to produce cortisol. \u003ca href=\"https:\/\/academic.oup.com\/jcem\/article\/88\/1\/450\/2846096\" target=\"_blank\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21332028\" target=\"_blank\"\u003ehere. \u003c\/a\u003e* Studies have shown that melatonin can reduce symptoms of stress in canines, including refusal to eat, excessive pacing or panting, as well as whimpering and licking. Melatonin may also help reduce aggressive behavior in dogs. Because the body responds to stress by producing additional cortisol, the reduction in stress, anxiety and aggression that results from melatonin supplementation may have a secondary effect (beyond the direct effects noted above) of lowering cortisol levels. * \u003cb\u003eNote:\u003c\/b\u003e Always consult your physician or veterinarian before taking melatonin for yourself or your dog. For treatment of dogs, you should not use a rapid release melatonin or a timed-release melatonin. Use only regular melatonin. All of our \u003ca href=\"https:\/\/www.lignans.net\/product-category\/dogs\/melatonin-dogs\/\"\u003emelatonin products\u003c\/a\u003e fit these criteria. \u003ca href=\"https:\/\/www.veterinaryplace.com\/dog-medicine\/melatonin\/\" target=\"_blank\"\u003eSee the recommended treatment protocols here.\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003eDirections for Dogs\u003c\/h3\u003e\n\u003cp\u003eThe University of Tennessee College of Veterinary Medicine recommends, and the late Dr. Jack Oliver, DVM, former Chairman of UofT's Veterinary Endocrinology Department, recommended: 3 mg of melatonin (3 tablets) every 12 hours for dogs under 30 lbs. 6 mg of melatonin (6 tablets) every 12 hours for dogs over 30 lbs. 1 mg of melatonin (1 tablet) every 12 hours may be recommended for dogs 10 lbs. or less, or for those who want to give their dogs very low doses of melatonin. \u003ca href=\"https:\/\/www.lignans.net\/melatonin-dosage-for-dogs.html\" target=\"_blank\"\u003eRecommended dosages for dogs.\u003c\/a\u003e Melatonin may also help anxious dogs by reducing stress hormone levels. * For this use, give 1 serving 30 minutes before stressful event.\u003c\/p\u003e","brand":"Lignans","offers":[{"title":"Default Title","offer_id":45554611224858,"sku":"20001","price":14.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/0362\/8570\/files\/1mgBeef-GalleryImage1_c3e45523-87a1-4e83-900e-4a698e673df7.jpg?v=1733488463"},{"product_id":"melatonin-3-mg-100-tablets-k9-select-brand-for-dogs","title":"K9 Select 3mg (unflavored) Melatonin","description":"\u003ch1\u003eK9 Select Melatonin 3 mg For Dogs\u003c\/h1\u003e\n\u003cp\u003e\u003cb\u003e\u003c\/b\u003e100 tablets, 100 (3 mg.) servings Each bottle contains 100 tablets of 3 mg of human-grade melatonin for dogs. Our K9 Select brand \u003ca href=\"https:\/\/www.lignans.net\/product-category\/dogs\/melatonin-dogs\/\"\u003emelatonin supplement for dogs\u003c\/a\u003e comes in chewable tablets, carefully formulated to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePromotes a natural sleep-wake cycle *\u003c\/li\u003e\n\u003cli\u003eProvides natural hormone support *\u003c\/li\u003e\n\u003cli\u003ePromotes relaxation, calm and comfort *\u003c\/li\u003e\n\u003cli\u003eSupports overall health – promotes normal thirst and urination *\u003c\/li\u003e\n\u003cli\u003eDaily use promotes normal skin and coat health *\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow Melatonin Works\u003c\/h3\u003e\n\u003cp\u003eIn humans, dogs, and other animals, melatonin plays an important role in the regulation of the sleep-wake cycle. Melatonin is naturally produced by the body in the pineal system. In healthy animals, peak production of melatonin naturally occurs after sunset. Melatonin signals to the body both time of day and season (length of night). However natural production decreases as we and our pets age. This is one reason older people and pets find it difficult to get quality sleep or to sleep for as many hours as when we were younger.\u003c\/p\u003e\n\u003ch3\u003eDirections for Dogs\u003c\/h3\u003e\n\u003cp\u003eThe University of Tennessee College of Veterinary Medicine recommends, and the late Dr. Jack Oliver, DVM, former Chairman of UofT's Veterinary Endocrinology Department, recommended:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e3 mg of melatonin (1 tablet) every 12 hours for dogs under 30 lbs.\u003c\/li\u003e\n\u003cli\u003e6 mg of melatonin (2 tablets) every 12 hours for dogs over 30 lbs.\u003c\/li\u003e\n\u003cli\u003e1 mg of melatonin (you may cut the tablet in half) every 12 hours may be recommended for dogs 10 lbs. or less, or for those who want to give their dogs very low doses of melatonin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003e** \u003c\/strong\u003eFor stressful events like traveling, vet visits, and parties, give 1 serving 30 minutes before event.\u003c\/span\u003e \u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003e*** Note\u003c\/strong\u003e: Always consult your veterinarian before giving dogs new supplements.\u003c\/span\u003e \u003ca href=\"https:\/\/www.lignans.net\/melatonin-dosage-for-dogs.html\" target=\"_blank\"\u003eRecommended dosages for dogs.\u003c\/a\u003e  \u003c\/p\u003e\n\u003ch3\u003eMelatonin Health Benefits\u003c\/h3\u003e\n\u003cp\u003eSupplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and promotes relaxation, calm and comfort. * Melatonin decreases sex hormone secretion, modulates aromatase activity, and inhibits cortisol production. It has also been shown in some animal models to inhibit androgen production and ovarian activity.\u003ca href=\"https:\/\/avmajournals.avma.org\/doi\/abs\/10.2460\/ajvr.72.5.675\" target=\"_blank\"\u003e Further reading here. \u003c\/a\u003eMelatonin’s anti-estrogenic properties have been extensively studied. Melatonin acts in several ways to limit estrogen production and\/or activities, including by interfering with estrogen receptor activities, down regulating estrogen expression during transcription, reducing estrogen receptor sensitivity, and inhibiting the expression of key enzymes (like aromatase) involved in estrogen production. \u003ca rel=\"noopener\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0301008208000348\" target=\"_blank\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.omicsonline.org\/open-access\/melatonininduced-oncostasis-mechanisms-and-clinical-relevance-2329-6771-S1-006.php?aid=68975\" target=\"_blank\"\u003ehere.\u003c\/a\u003e In addition, melatonin has been shown not only to inhibit cortisol itself, but also the chemical (ACTH) that signals the adrenal gland to produce cortisol. \u003ca href=\"https:\/\/academic.oup.com\/jcem\/article\/88\/1\/450\/2846096\" target=\"_blank\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21332028\" target=\"_blank\"\u003ehere. \u003c\/a\u003e* Studies have shown that melatonin can reduce symptoms of stress in canines, including refusal to eat, excessive pacing or panting, as well as whimpering and licking. Melatonin may also help reduce aggressive behavior in dogs. Because the body responds to stress by producing additional cortisol, the reduction in stress, anxiety and aggression that results from melatonin supplementation may have a secondary effect (beyond the direct effects noted above) of lowering cortisol levels. * \u003cb\u003eNote:\u003c\/b\u003e Always consult your veterinarian before giving melatonin to your dog. For treatment of dogs, you should not use a rapid release melatonin or a time-release melatonin. Use only regular melatonin. All of our melatonin products fit these criteria. \u003ca href=\"https:\/\/www.veterinaryplace.com\/dog-medicine\/melatonin\/\" target=\"_blank\"\u003eSee the recommended treatment protocols here.\u003c\/a\u003e\u003c\/p\u003e","brand":"Lignans","offers":[{"title":"Default Title","offer_id":45554611421466,"sku":"20003","price":13.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/0362\/8570\/files\/3mg-GalleryImage1.jpg?v=1729436276"},{"product_id":"k9-select-chewable-3-mg-melatonin-for-dogs-beef-flavor-120-tabs","title":"3mg Beef Melatonin","description":"\u003ch2\u003e\n\u003cstrong\u003eK9 Select Melatonin for Dogs 3mg, 120ct \u003c\/strong\u003e\u003cstrong\u003eBeef Flavored Chewable Tablets\u003c\/strong\u003e\n\u003c\/h2\u003e\n\u003cb\u003e\u003c\/b\u003e120 Chewable Tablets, 120 3 mg. servings. Each bottle contains 120 chewable tablets of 3 mg human-grade melatonin in a beef liver flavor that dogs love! Our K9 Select brand melatonin supplements for dogs are carefully formulated to:\n\u003cul\u003e\n\u003cli\u003ePromote a natural sleep-wake cycle *\u003c\/li\u003e\n\u003cli\u003eProvide natural hormone support *\u003c\/li\u003e\n\u003cli\u003ePromote relaxation, calm and comfort *\u003c\/li\u003e\n\u003cli\u003eSupport overall health – promote normal thirst and urination *\u003c\/li\u003e\n\u003cli\u003eDaily use promotes normal skin and coat health *\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow Melatonin Works\u003c\/h3\u003e\nIn humans, dogs, and other animals, melatonin plays an important role in the regulation of the sleep-wake cycle. Melatonin is naturally produced by the body in the pineal system. In healthy animals, peak production of melatonin naturally occurs after sunset. Melatonin signals to the body both time of day and season (length of night). However natural production decreases as we and our pets age. This is one reason older people and pets find it difficult to get quality sleep or to sleep for as many hours as when we were younger.\n\u003ch3\u003eMelatonin Health Benefits\u003c\/h3\u003e\nSupplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and anxiety. * Melatonin decreases sex hormone secretion, modulates aromatase activity, and inhibits cortisol production. It has also been shown in some animal models to inhibit androgen production and ovarian activity.\u003ca href=\"https:\/\/avmajournals.avma.org\/doi\/abs\/10.2460\/ajvr.72.5.675\" target=\"_blank\"\u003e Further reading here. \u003c\/a\u003eMelatonin’s anti-estrogenic properties have been extensively studied. Melatonin acts in several ways to limit estrogen production and\/or activities, including by interfering with estrogen receptor activities, down regulating estrogen expression during transcription, reducing estrogen receptor sensitivity, and inhibiting the expression of key enzymes (like aromatase) involved in estrogen production. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0301008208000348\" target=\"_blank\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.omicsonline.org\/open-access\/melatonininduced-oncostasis-mechanisms-and-clinical-relevance-2329-6771-S1-006.php?aid=68975\" target=\"_blank\"\u003ehere.\u003c\/a\u003e In addition, melatonin has been shown not only to inhibit cortisol itself, but also the chemical (ACTH) that signals the adrenal gland to produce cortisol. \u003ca href=\"https:\/\/academic.oup.com\/jcem\/article\/88\/1\/450\/2846096\" target=\"_blank\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21332028\" target=\"_blank\"\u003ehere. \u003c\/a\u003e* Studies have shown that melatonin can reduce symptoms of stress in canines, including refusal to eat, excessive pacing or panting, as well as whimpering and licking. Melatonin may also help reduce aggressive behavior in dogs. Because the body responds to stress by producing additional cortisol, the reduction in stress, anxiety and aggression that results from melatonin supplementation may have a secondary effect (beyond the direct effects noted above) of lowering cortisol levels. * \u003cb\u003eNote:\u003c\/b\u003e Always consult your physician or veterinarian before taking melatonin for yourself or your dog. For treatment of dogs, you should not use a rapid release melatonin or a timed-release melatonin. Use only regular melatonin. All of our melatonin products fit these criteria. \u003ca href=\"https:\/\/www.veterinaryplace.com\/dog-medicine\/melatonin\/\" target=\"_blank\"\u003eSee the recommended treatment protocols here.\u003c\/a\u003e\n\u003ch3\u003eDirections for Dogs\u003c\/h3\u003e\nThe University of Tennessee College of Veterinary Medicine recommends, and the late Dr. Jack Oliver, DVM, former Chairman of UofT's Veterinary Endocrinology Department, recommended:\n\u003cul\u003e\n\u003cli\u003e3 mg of melatonin (1 tablet) every 12 hours for dogs under 30 lbs.\u003c\/li\u003e\n\u003cli\u003e6 mg of melatonin (2 tablets) every 12 hours for dogs over 30 lbs.\u003c\/li\u003e\n\u003cli\u003e1 mg of melatonin (you may cut the tablet in half) every 12 hours may be recommended for dogs 10 lbs. or less, or for those who want to give their dogs very low doses of melatonin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ca href=\"https:\/\/www.lignans.net\/melatonin-dosage-for-dogs.html\" target=\"_blank\"\u003eRecommended dosages for dogs.\u003c\/a\u003e Melatonin may also help anxious dogs by reducing stress hormone levels. * For this use, give 1 serving 30 minutes before stressful event.","brand":"Lignans","offers":[{"title":"Default Title","offer_id":49850903691546,"sku":"20004","price":15.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/0362\/8570\/files\/3mgBeef-GalleryImage1.jpg?v=1733488488"},{"product_id":"k9-choice-chewable-3-mg-melatonin-for-dogs-peanut-butter-flavor-120-tabs","title":"3mg Peanut Butter Melatonin","description":"\u003ch2\u003e\n\u003cstrong\u003eK9 Select Melatonin for Dogs 3mg, 120ct \u003c\/strong\u003e\u003cstrong\u003ePeanut Butter Flavored Tablets\u003c\/strong\u003e\n\u003c\/h2\u003e\n\u003cp\u003e\u003cb\u003e\u003c\/b\u003e120 Chewable Tablets, 120 3 mg. servings.  Each bottle contains 120 chewable tablets of 3 mg human-grade melatonin for dogs in a peanut butter flavor that dogs love! Our K9 Select brand melatonin supplements for dogs are carefully formulated to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePromote a natural sleep-wake cycle *\u003c\/li\u003e\n\u003cli\u003eProvide natural hormone support *\u003c\/li\u003e\n\u003cli\u003ePromote relaxation, calm and comfort *\u003c\/li\u003e\n\u003cli\u003eSupport overall health – promote normal thirst and urination *\u003c\/li\u003e\n\u003cli\u003eDaily use promotes normal skin and coat health *\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow Melatonin for Dogs Works\u003c\/h3\u003e\n\u003cp\u003eIn humans, dogs, and other animals, melatonin plays an important role in the regulation of the sleep-wake cycle. Melatonin is naturally produced by the body in the pineal system. In healthy animals, peak production of melatonin naturally occurs after sunset. Melatonin signals to the body both time of day and season (length of night). However natural production decreases as we and our pets age. This is one reason older people and pets find it difficult to get quality sleep or to sleep for as many hours as when we were younger.\u003c\/p\u003e\n\u003ch3\u003eMelatonin Health Benefits\u003c\/h3\u003e\n\u003cp\u003eSupplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and anxiety. * Melatonin decreases sex hormone secretion, modulates aromatase activity, and inhibits cortisol production. It has also been shown in some animal models to inhibit androgen production and ovarian activity.\u003ca href=\"https:\/\/avmajournals.avma.org\/doi\/abs\/10.2460\/ajvr.72.5.675\" target=\"_blank\"\u003e Further reading here. \u003c\/a\u003eMelatonin’s anti-estrogenic properties have been extensively studied. Melatonin acts in several ways to limit estrogen production and\/or activities, including by interfering with estrogen receptor activities, down regulating estrogen expression during transcription, reducing estrogen receptor sensitivity, and inhibiting the expression of key enzymes (like aromatase) involved in estrogen production. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0301008208000348\" target=\"_blank\" rel=\"noopener\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.omicsonline.org\/open-access\/melatonininduced-oncostasis-mechanisms-and-clinical-relevance-2329-6771-S1-006.php?aid=68975\" target=\"_blank\"\u003ehere.\u003c\/a\u003e In addition, melatonin has been shown not only to inhibit cortisol itself, but also the chemical (ACTH) that signals the adrenal gland to produce cortisol. \u003ca href=\"https:\/\/academic.oup.com\/jcem\/article\/88\/1\/450\/2846096\" target=\"_blank\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21332028\" target=\"_blank\"\u003ehere. \u003c\/a\u003e* Studies have shown that melatonin can reduce symptoms of stress in canines, including refusal to eat, excessive pacing or panting, as well as whimpering and licking. Melatonin may also help reduce aggressive behavior in dogs. Because the body responds to stress by producing additional cortisol, the reduction in stress, anxiety and aggression that results from melatonin supplementation may have a secondary effect (beyond the direct effects noted above) of lowering cortisol levels. * \u003cb\u003eNote:\u003c\/b\u003e Always consult your physician or veterinarian before taking melatonin for yourself or your dog. For treatment of dogs, you should not use a rapid release melatonin or a timed-release melatonin. Use only regular melatonin. All of our melatonin products fit these criteria. \u003ca href=\"https:\/\/www.veterinaryplace.com\/dog-medicine\/melatonin\/\" target=\"_blank\"\u003eSee the recommended treatment protocols here.\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003eDirections for Dogs\u003c\/h3\u003e\n\u003cp\u003eThe University of Tennessee College of Veterinary Medicine recommends, and the late Dr. Jack Oliver, DVM, former Chairman of UofT's Veterinary Endocrinology Department, recommended:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e3 mg of melatonin (1 tablet) every 12 hours for dogs under 30 lbs.\u003c\/li\u003e\n\u003cli\u003e6 mg of melatonin (2 tablets) every 12 hours for dogs over 30 lbs.\u003c\/li\u003e\n\u003cli\u003e1 mg of melatonin (you may cut the tablet in half) every 12 hours may be recommended for dogs 10 lbs. or less, or for those who want to give their dogs very low doses of melatonin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.lignans.net\/melatonin-dosage-for-dogs.html\" target=\"_blank\"\u003eRecommended dosages for dogs.\u003c\/a\u003e Melatonin may also help anxious dogs by reducing stress hormone levels. * For this use, give 1 serving 30 minutes before stressful event.\u003c\/p\u003e","brand":"Lignans","offers":[{"title":"Default Title","offer_id":45554611585306,"sku":"20014","price":16.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/0362\/8570\/files\/3mgPeanut-GalleryImage1.jpg?v=1733488435"},{"product_id":"k9-select-melatonin-5-mg-180-tablets","title":"5mg Melatonin","description":"\u003ch1\u003eK9 Select Melatonin 5 mg For Dogs\u003c\/h1\u003e\n\u003cp\u003e\u003cb\u003e\u003c\/b\u003e180 tablets. 180 5 mg. servings. Each bottle contains 180 tablets of 5 mg of human-grade \u003ca href=\"https:\/\/www.lignans.net\/product-category\/dogs\/melatonin-dogs\/\"\u003emelatonin for dogs\u003c\/a\u003e. Our K9 Select brand melatonin supplements for dogs are carefully formulated to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePromote a natural sleep-wake cycle *\u003c\/li\u003e\n\u003cli\u003eProvide natural hormone support *\u003c\/li\u003e\n\u003cli\u003eSupport overall health - promote normal thirst and urination *\u003c\/li\u003e\n\u003cli\u003ePromote relaxation, calm and comfort *\u003c\/li\u003e\n\u003cli\u003eDaily use promotes normal skin and coat health *\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow Melatonin Works\u003c\/h3\u003e\n\u003cp\u003eIn humans, dogs, and other animals, melatonin plays an important role in the regulation of the sleep-wake cycle. Melatonin is naturally produced by the body in the pineal system. In healthy animals, peak production of melatonin naturally occurs after sunset. Melatonin signals to the body both time of day and season (length of night). However natural production decreases as we and our pets age. This is one reason older people and pets find it difficult to get quality sleep or to sleep for as many hours as when we were younger.\u003c\/p\u003e\n\u003ch3\u003eMelatonin Health Benefits\u003c\/h3\u003e\n\u003cp\u003eSupplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and anxiety. * Melatonin decreases sex hormone secretion, modulates aromatase activity, and inhibits cortisol production. It has also been shown in some animal models to inhibit androgen production and ovarian activity.\u003ca rel=\"noopener noreferrer\" href=\"https:\/\/avmajournals.avma.org\/doi\/abs\/10.2460\/ajvr.72.5.675\" target=\"_blank\"\u003e Further reading here. \u003c\/a\u003eMelatonin’s anti-estrogenic properties have been extensively studied. Melatonin acts in several ways to limit estrogen production and\/or activities, including by interfering with estrogen receptor activities, down regulating estrogen expression during transcription, reducing estrogen receptor sensitivity, and inhibiting the expression of key enzymes (like aromatase) involved in estrogen production. \u003ca rel=\"noopener noreferrer\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0301008208000348\" target=\"_blank\"\u003eFurther reading here\u003c\/a\u003e and \u003ca rel=\"noopener noreferrer\" href=\"https:\/\/www.omicsonline.org\/open-access\/melatonininduced-oncostasis-mechanisms-and-clinical-relevance-2329-6771-S1-006.php?aid=68975\" target=\"_blank\"\u003ehere.\u003c\/a\u003e In addition, melatonin has been shown not only to inhibit cortisol itself, but also the chemical (ACTH) that signals the adrenal gland to produce cortisol. \u003ca rel=\"noopener noreferrer\" href=\"https:\/\/academic.oup.com\/jcem\/article\/88\/1\/450\/2846096\" target=\"_blank\"\u003eFurther reading here\u003c\/a\u003e and \u003ca rel=\"noopener noreferrer\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21332028\" target=\"_blank\"\u003ehere. \u003c\/a\u003e* Studies have shown that melatonin can reduce symptoms of stress in canines, including refusal to eat, excessive pacing or panting, as well as whimpering and licking. Melatonin may also help reduce aggressive behavior in dogs. Because the body responds to stress by producing additional cortisol, the reduction in stress, anxiety and aggression that results from melatonin supplementation may have a secondary effect (beyond the direct effects noted above) of lowering cortisol levels. * \u003cb\u003eNote:\u003c\/b\u003e Always consult your physician or veterinarian before taking melatonin for yourself or your dog. For treatment of dogs, you should not use a rapid release melatonin or a timed-release melatonin. Use only regular melatonin. All of our melatonin products fit these criteria. \u003ca rel=\"noopener noreferrer\" href=\"https:\/\/www.veterinaryplace.com\/dog-medicine\/melatonin\/\" target=\"_blank\"\u003eSee the recommended treatment protocols here.\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003eDirections for Dogs\u003c\/h3\u003e\n\u003cp\u003eThe University of Tennessee College of Veterinary Medicine recommends, and the late Dr. Jack Oliver, DVM, former Chairman of UofT's Veterinary Endocrinology Department, recommended:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e3 mg of melatonin (approximately 1\/2 tablet) every 12 hours for dogs under 30 lbs.\u003c\/li\u003e\n\u003cli\u003e6 mg of melatonin (approximately 1 tablet) every 12 hours for dogs over 30 lbs.\u003c\/li\u003e\n\u003cli\u003e1 mg of melatonin (you may cut the tablet in fourths) every 12 hours may be recommended for dogs 10 lbs. or less, or for those who want to give their dogs very low doses of melatonin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003ca rel=\"noopener noreferrer\" href=\"https:\/\/www.lignans.net\/melatonin-dosage-for-dogs.html\" target=\"_blank\"\u003eRecommended dosages for dogs.\u003c\/a\u003e Melatonin may also help anxious dogs by reducing stress hormone levels. * For this use, give 1 serving 30 minutes before stressful event.\u003c\/p\u003e","brand":"Lignans","offers":[{"title":"Default Title","offer_id":45554611618074,"sku":"20005","price":18.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/0362\/8570\/files\/5mg-GalleryImage1.jpg?v=1729435138"},{"product_id":"lignans-for-life-melatonin-6mg-120-capsules","title":"6mg Melatonin","description":"\u003ch1\u003eLignans for Life Melatonin 6 mg for People or Dogs\u003c\/h1\u003e\n\u003cp\u003e120 capsules. 120 (6 mg) servings. Each bottle contains 120 capsules of 6 mg human-grade melatonin for humans or dogs.  Our Lignans for Life brand melatonin supplement is carefully formulated to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePromote a natural sleep-wake cycle *\u003c\/li\u003e\n\u003cli\u003eProvide natural hormone support *\u003c\/li\u003e\n\u003cli\u003ePromote relaxation, calm and comfort *\u003c\/li\u003e\n\u003cli\u003eSupport overall health *\u003c\/li\u003e\n\u003cli\u003eDaily use promotes normal skin health *\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow Melatonin Works\u003c\/h3\u003e\n\u003cp\u003eIn humans, dogs, and other animals, melatonin plays an important role in the regulation of the sleep-wake cycle. Melatonin is naturally produced by the body in the pineal system. In healthy animals, peak production of melatonin naturally occurs after sunset. Melatonin signals to the body both time of day and season (length of night). However natural production decreases as we and our pets age. This is one reason older people and pets find it difficult to get quality sleep or to sleep for as many hours as when we were younger.\u003c\/p\u003e\n\u003ch3\u003eMelatonin Health Benefits\u003c\/h3\u003e\n\u003cp\u003eSupplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and anxiety. * Melatonin decreases sex hormone secretion, modulates aromatase activity, and inhibits cortisol production. It has also been shown in some animal models to inhibit androgen production and ovarian activity.\u003ca href=\"https:\/\/avmajournals.avma.org\/doi\/abs\/10.2460\/ajvr.72.5.675\" rel=\"noopener noreferrer\" target=\"_blank\"\u003e Further reading here. \u003c\/a\u003eMelatonin’s anti-estrogenic properties have been extensively studied. Melatonin acts in several ways to limit estrogen production and\/or activities, including by interfering with estrogen receptor activities, down regulating estrogen expression during transcription, reducing estrogen receptor sensitivity, and inhibiting the expression of key enzymes (like aromatase) involved in estrogen production. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0301008208000348\" rel=\"noopener noreferrer\" target=\"_blank\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.omicsonline.org\/open-access\/melatonininduced-oncostasis-mechanisms-and-clinical-relevance-2329-6771-S1-006.php?aid=68975\" rel=\"noopener noreferrer\" target=\"_blank\"\u003ehere.\u003c\/a\u003e In addition, melatonin has been shown not only to inhibit cortisol itself, but also the chemical (ACTH) that signals the adrenal gland to produce cortisol. \u003ca href=\"https:\/\/academic.oup.com\/jcem\/article\/88\/1\/450\/2846096\" rel=\"noopener noreferrer\" target=\"_blank\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21332028\" rel=\"noopener noreferrer\" target=\"_blank\"\u003ehere. \u003c\/a\u003e* Studies have shown that melatonin can reduce symptoms of stress in canines, including refusal to eat, excessive pacing or panting, as well as whimpering and licking. Melatonin may also help reduce aggressive behavior in dogs. Because the body responds to stress by producing additional cortisol, the reduction in stress, anxiety and aggression that results from melatonin supplementation may have a secondary effect (beyond the direct effects noted above) of lowering cortisol levels. * \u003cb\u003eNote:\u003c\/b\u003e Always consult your physician or veterinarian before taking melatonin for yourself or your dog. For treatment of dogs, you should not use a rapid release melatonin or a timed-release melatonin. Use only regular melatonin. All of our melatonin products fit these criteria. \u003ca href=\"https:\/\/www.veterinaryplace.com\/dog-medicine\/melatonin\/\" rel=\"noopener noreferrer\" target=\"_blank\"\u003eSee the recommended treatment protocols here.\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003eDirections for Dogs\u003c\/h3\u003e\n\u003cp\u003eThe University of Tennessee College of Veterinary Medicine recommends, and the late Dr. Jack Oliver, DVM, former Chairman of UofT's Veterinary Endocrinology Department, recommended:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e3 mg of melatonin (1\/2 capsule) every 12 hours for dogs under 30 lbs.\u003c\/li\u003e\n\u003cli\u003e6 mg of melatonin (1 capsule) every 12 hours for dogs over 30 lbs.\u003c\/li\u003e\n\u003cli\u003e1 mg of melatonin (you may open the capsule) every 12 hours may be recommended for dogs 10 lbs. or less, or for those who want to give their dogs very low doses of melatonin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.lignans.net\/melatonin-dosage-for-dogs.html\" rel=\"noopener noreferrer\" target=\"_blank\"\u003eRecommended dosages for dogs.\u003c\/a\u003e Melatonin may also help anxious dogs by reducing stress hormone levels. * For this use, give 1 serving 30 minutes before stressful event.\u003c\/p\u003e","brand":"Lignans","offers":[{"title":"Default Title","offer_id":45554611683610,"sku":"20006","price":15.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/0362\/8570\/files\/6mg-GalleryImage1.jpg?v=1729435343"},{"product_id":"6-mg-melatonin-for-dogs-beef-flavor","title":"6 mg Melatonin for Dogs: Beef Flavor","description":"\u003ch1\u003eK9 Select Melatonin 6 mg For Dogs: Beef Flavored Chewable Tablet\u003c\/h1\u003e\n\u003cp\u003e90 tablets. 90 servings of 6 mg. Each bottle contains 90 tablets of 6 mg beef flavored \u003ca href=\"https:\/\/www.lignans.net\/product-category\/dogs\/melatonin-dogs\/\"\u003emelatonin for dogs\u003c\/a\u003e. Our K9 Select brand melatonin supplements for dogs are carefully formulated to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePromote a natural sleep-wake cycle *\u003c\/li\u003e\n\u003cli\u003eProvide natural hormone support *\u003c\/li\u003e\n\u003cli\u003ePromote relaxation, calm and comfort *\u003c\/li\u003e\n\u003cli\u003eSupport overall health – promote normal thirst and urination *\u003c\/li\u003e\n\u003cli\u003eDaily use promotes normal skin and coat health *\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow Melatonin Works\u003c\/h3\u003e\n\u003cp\u003eIn humans, dogs, and other animals, melatonin plays an important role in the regulation of the sleep-wake cycle. Melatonin is naturally produced by the body in the pineal system. In healthy animals, peak production of melatonin naturally occurs after sunset. Melatonin signals to the body both time of day and season (length of night). However natural production decreases as we and our pets age. This is one reason older people and pets find it difficult to get quality sleep or to sleep for as many hours as when we were younger.\u003c\/p\u003e\n\u003ch3\u003eMelatonin Health Benefits\u003c\/h3\u003e\n\u003cp\u003eSupplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and anxiety. * Melatonin decreases sex hormone secretion, modulates aromatase activity, and inhibits cortisol production. It has also been shown in some animal models to inhibit androgen production and ovarian activity. \u003ca href=\"https:\/\/avmajournals.avma.org\/doi\/abs\/10.2460\/ajvr.72.5.675\"\u003eFurther reading here\u003c\/a\u003e. Melatonin’s anti-estrogenic properties have been extensively studied. Melatonin acts in several ways to limit estrogen production and\/or activities, including by interfering with estrogen receptor activities, down-regulating estrogen expression during transcription, reducing estrogen receptor sensitivity, and inhibiting the expression of key enzymes (like aromatase) involved in estrogen production. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0301008208000348\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.omicsonline.org\/open-access\/melatonininduced-oncostasis-mechanisms-and-clinical-relevance-2329-6771-S1-006.php?aid=68975\"\u003ehere\u003c\/a\u003e. In addition, melatonin has been shown not only to inhibit cortisol itself, but also the chemical (ACTH) that signals the adrenal gland to produce cortisol. \u003ca href=\"https:\/\/academic.oup.com\/jcem\/article\/88\/1\/450\/2846096\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21332028\"\u003ehere\u003c\/a\u003e.  * Studies have shown that melatonin can reduce symptoms of stress in canines, including refusal to eat, excessive pacing or panting, as well as whimpering and licking. Melatonin may also help reduce aggressive behavior in dogs. Because the body responds to stress by producing additional cortisol, the reduction in stress, anxiety and aggression that results from melatonin supplementation may have a secondary effect (beyond the direct effects noted above) of lowering cortisol levels. * \u003cstrong\u003eNote:\u003c\/strong\u003e Always consult your physician or veterinarian before taking melatonin for yourself or for your dog. For treatment of dogs, you should not use a rapid release melatonin or a timed-release melatonin. Use only regular melatonin. All of our melatonin products fit these criteria. \u003ca href=\"https:\/\/www.veterinaryplace.com\/dog-medicine\/melatonin\/\"\u003eSee the recommended treatment protocols here\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eDirections for Dogs\u003c\/h3\u003e\n\u003cp\u003eThe University of Tennessee College of Veterinary Medicine recommends, and the late Dr. Jack Oliver, DVM, former Chairman of UofT's Veterinary Endocrinology Department, recommended:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e6 mg of melatonin (1 tablet) every 12 hours for dogs over 30 lbs.\u003c\/li\u003e\n\u003cli\u003e3 mg of melatonin (1\/2 tablet) every 12 hours for dogs under 30 lbs.\u003c\/li\u003e\n\u003cli\u003e1 mg of melatonin (see our \u003ca href=\"https:\/\/www.lignans.net\/product\/k9-select-chewable-1-mg-melatonin-for-dogs-beef-flavor-180-tabs\/\"\u003e1 mg tablet\u003c\/a\u003e) every 12 hours may be recommended for dogs 10 lbs. or less, or for those who want to give their dogs very low doses of melatonin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.lignans.net\/melatonin-dosage-for-dogs\"\u003eRecommended dosages for dogs\u003c\/a\u003e. Melatonin may also help anxious dogs by reducing stress hormone levels. * For this use, give 1 serving 30 minutes before stressful event.\u003c\/p\u003e","brand":"Lignans","offers":[{"title":"Default Title","offer_id":52393203728666,"sku":"20029","price":19.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/0362\/8570\/files\/Screenshot2024-10-20at16.11.11.png?v=1729437101"},{"product_id":"hmr-multi-formula-30mg-beef","title":"HMR Multi-Formula 30mg Beef Flavored Tablets","description":"\u003ch2\u003e\u003cstrong\u003eK9 Select Multi-Formula (HMR Lignans, Melatonin, Milk Thistle) 30mg, 90 Tablets\u003c\/strong\u003e\u003c\/h2\u003e\n\u003ch3\u003eBeef and Cheddar Cheese Flavored\u003c\/h3\u003e\n\u003cp\u003eEach bottle contains 90 beef and cheddar cheese flavored tablets for dogs. Three products combined into one flavored tablet for 90 servings of:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHMR Lignans 30 mg\u003c\/li\u003e\n\u003cli\u003eMelatonin 3 mg\u003c\/li\u003e\n\u003cli\u003eMilk Thistle 60 mg\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eWe are proud to introduce our new combination HMR products!\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eTasty beef and cheddar flavored tablets that your dog will love! Our K9 Select HMR Multi-Formula supplements for dogs are carefully formulated to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eProvide natural hormone support *\u003c\/li\u003e\n\u003cli\u003eHelp balance estrogen, cortisol and testosterone *\u003c\/li\u003e\n\u003cli\u003ePromote a healthy immune system *\u003c\/li\u003e\n\u003cli\u003ePromote relaxation, calm and comfort *\u003c\/li\u003e\n\u003cli\u003eSupport overall health – promote normal thirst and urination *\u003c\/li\u003e\n\u003cli\u003eDaily use promotes normal skin and coat health *\u003c\/li\u003e\n\u003cli\u003eProvide natural liver support *\u003c\/li\u003e\n\u003cli\u003eProvide natural antioxidants *\u003c\/li\u003e\n\u003cli\u003eBottled in the USA\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe first active ingredient is HMR lignans. Like our Lignans for Life HMR lignans, our K9 Select lignans are sourced from the same Norwegian spruce tree knots. HMR is short for hydroxymatairesinol, which is metabolized in the body into a powerful antioxidant that prevents or limits oxidative stress throughout the body and supports the immune system. Many studies indicate that high amounts of lignans in the body may reduce cortisol and other hormone levels and promote healthy reproductive organs. * The second active ingredient is melatonin. Supplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and anxiety. * The third active ingredient is milk thistle, standardized to 80% Silymarin. Research suggests that Silymarin (the flavolignans removed from milk thistle) and its antioxidant properties can be beneficial for dogs (5). Studies also suggest that milk thistle may support a healthy liver in dogs. Milk Thistle can be beneficial for dogs with Cushings Disease (a common adrenal disorder), as liver problems are often associated with the disease due to the stress it places on the liver.\u003c\/p\u003e\n\u003ch3\u003eOther HMR Multi-Formula options:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eHMR Multi-Formula 20mg unflavored capsules for \u003cstrong\u003emedium dogs\u003c\/strong\u003e: \u003ca href=\"https:\/\/www.lignans.net\/product\/hmr-multi-formula-20mg-capsules\/\"\u003ehttps:\/\/www.lignans.net\/product\/hmr-multi-formula-20mg-capsules\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eHMR Multi-Formula 10mg peanut butter chewable tablets for \u003cstrong\u003esmall dogs\u003c\/strong\u003e: \u003ca href=\"https:\/\/www.lignans.net\/product\/hmr-multi-formula-10mg-peanut-butter\/\"\u003ehttps:\/\/www.lignans.net\/product\/hmr-multi-formula-10mg-peanut-butter\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eLignans Health Benefits\u003c\/h2\u003e\n\u003cp\u003eLignans are excellent for balancing hormone levels in the body. Specifically, lignans have been shown to reduce cortisol and other adrenal steroids and to exert anti-estrogenic effects. Such anti-estrogenic effects include the prevention of naturally occurring hormones from binding to estrogen receptors and exerting their negative effects. Lignans provide a weaker form of estrogen. Thus, they are believed to be helpful in balancing out both estrogen deficiencies (by supplying phytoestrogens to otherwise inactive receptors) and excesses (through at least two separate mechanisms – first, by competing with much stronger estrogen for the same receptors and second, by inhibiting aromatase activity). \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4375225\/\" target=\"_blank\"\u003eFurther reading here.\u003c\/a\u003e*\u003c\/p\u003e\n\u003ch3\u003eResearch\u003c\/h3\u003e\n\u003cp\u003eLignans are converted in the body into the mammalian lignans (enterolignans) enterodiol and enterolactone. Enterolignans have been shown to be potent antioxidants. They reduce the free radicals that otherwise damage tissues, membrane lipids, nucleic acids, and proteins, and may lead to diseases or premature aging. Enterolignans also stimulate the synthesis of sex hormone binding globulin, effectively binding sex hormones and thereby reducing their circulation in the blood stream and thus their biological activity. * Some studies have indicated improved hair growth. *  \u003c\/p\u003e\n\u003ch2\u003eMelatonin Health Benefits\u003c\/h2\u003e\n\u003cp\u003eSupplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and anxiety. * Melatonin decreases sex hormone secretion, modulates aromatase activity, and inhibits cortisol production. It has also been shown in some animal models to inhibit androgen production and ovarian activity. \u003ca href=\"https:\/\/avmajournals.avma.org\/doi\/abs\/10.2460\/ajvr.72.5.675\"\u003eFurther reading here\u003c\/a\u003e. Melatonin’s anti-estrogenic properties have been extensively studied. Melatonin acts in several ways to limit estrogen production and\/or activities, including by interfering with estrogen receptor activities, down-regulating estrogen expression during transcription, reducing estrogen receptor sensitivity, and inhibiting the expression of key enzymes (like aromatase) involved in estrogen production. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0301008208000348\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.omicsonline.org\/open-access\/melatonininduced-oncostasis-mechanisms-and-clinical-relevance-2329-6771-S1-006.php?aid=68975\"\u003ehere\u003c\/a\u003e. In addition, melatonin has been shown not only to inhibit cortisol itself, but also the chemical (ACTH) that signals the adrenal gland to produce cortisol. \u003ca href=\"https:\/\/academic.oup.com\/jcem\/article\/88\/1\/450\/2846096\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21332028\"\u003ehere\u003c\/a\u003e.  * Studies have shown that melatonin can reduce symptoms of stress in canines, including refusal to eat, excessive pacing or panting, as well as whimpering and licking. Melatonin may also help reduce aggressive behavior in dogs. Because the body responds to stress by producing additional cortisol, the reduction in stress, anxiety and aggression that results from melatonin supplementation may have a secondary effect (beyond the direct effects noted above) of lowering cortisol levels. * \u003ca href=\"https:\/\/www.veterinaryplace.com\/dog-medicine\/melatonin\/\"\u003eSee the recommended treatment protocols here\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eHow Melatonin Works\u003c\/h3\u003e\n\u003cp\u003eIn humans, dogs, and other animals, melatonin plays an important role in the regulation of the sleep-wake cycle. Melatonin is naturally produced by the body in the pineal system. In healthy animals, peak production of melatonin naturally occurs after sunset. Melatonin signals to the body both time of day and season (length of night). However natural production decreases as we and our pets age. This is one reason older people and pets find it difficult to get quality sleep or to sleep for as many hours as when we were younger. Melatonin may also help anxious dogs by reducing stress hormone levels. * For this use, give 1 serving melatonin products 30 minutes before stressful event. \u003ca href=\"https:\/\/www.lignans.net\/product-category\/dogs\/melatonin-dogs\/\"\u003eSee a full list of canine melatonin products here\u003c\/a\u003e. \u003cstrong\u003eNote:\u003c\/strong\u003e Always consult your physician or veterinarian before taking melatonin for yourself or for your dog. For treatment of dogs, you should not use a rapid release melatonin or a timed-release melatonin. Use only regular melatonin. All of our melatonin products fit these criteria.  \u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eMilk Thistle Health Benefits \u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eMilk Thistle is found in Europe, the Middle East and North Africa. Milk Thistle belongs to the daisy family and has been used for protection of the liver for thousands of years. Silymarin, a component of milk thistle seeds, or milk thistle extract, is a flavonoid that provides antioxidants naturally. Milk Thistle has been studied for its antioxidant properties that may support the liver(1). Other reported benefits of silymarin and milk thistle include their anti-inflammatory properties, which may support cell structure. Studies also imply that the active ingredients in milk thistle may support skin health Research suggests that Silymarin (the flavolignans removed from milk thistle) and its antioxidant properties can be beneficial for dogs (5). Studies also suggest that milk thistle may support a healthy liver in dogs. Milk Thistle can be beneficial for dogs with Cushings Disease (a common adrenal disorder), as liver problems are often associated with the disease due to the stress it places on the liver.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eMilk Thistle Side Effects\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eVery few side effects have been reported after using milk thistle. In rare cases, it may have a laxative effect, but such instances are uncommon. It is always important to consult your doctor or physician before starting any new supplement. \u003cb\u003eNote: \u003c\/b\u003eAn additional product to consider is SAMe for liver support. Milk Thistle and SAMe are often used together for added benefits. \u003ca href=\"https:\/\/www.lignans.net\/k9-same.html\"\u003eClick here to read about SAMe for dogs\u003c\/a\u003e  \u003c\/p\u003e\n\u003ch2\u003eGeneral Dosages \u0026amp; Directions\u003c\/h2\u003e\n\u003cp\u003eFor adult dogs, give 1 chewable tablet for every 30 lbs of body weight. Tablet can be administered whole as a treat or hidden in food. It can also be given with a small amount of peanut butter, a small piece of cheese, a pill pocket, etc. A second serving of melatonin is recommended later in the day, as noted below. \u003cstrong\u003eImportant Note\u003c\/strong\u003e: Lignans and Milk Thistle are recommended once per day. \u003cspan style=\"text-decoration: underline;\"\u003eMelatonin is recommended every 12 hours\u003c\/span\u003e, so a second serving of melatonin should be given 12 hours after the Multi-Formula tablet, as follows:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e6 mg of melatonin for dogs over 30 lbs.\u003c\/li\u003e\n\u003cli\u003e3 mg of melatonin for dogs under 30 lbs.\u003c\/li\u003e\n\u003cli\u003e1 mg of melatonin may be recommended for dogs 10 lbs. or less, or for those who want to give their dogs very low doses of melatonin.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.lignans.net\/product-category\/dogs\/melatonin-dogs\/\"\u003eSee a full list of canine melatonin products here\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e(Click the following link for more detailed info on \u003ca href=\"https:\/\/www.lignans.net\/lignans-dosage-for-dogs.html\" target=\"_blank\"\u003eLignans Dosage for Dogs.\u003c\/a\u003e Click the following link for more detailed info on \u003ca href=\"https:\/\/www.lignans.net\/melatonin-dosage-for-dogs\"\u003eMelatonin Dosages for Dogs\u003c\/a\u003e. Recommended milk thistle dosage for healthy dogs is approximately 2 mg of milk thistle for each pound of dog's weight.) \u003cb\u003eNote:\u003c\/b\u003e Always consult your veterinarian when trying new supplements.     \u003cb\u003eResearch\u003c\/b\u003e 1). Asghar Z, Masood Z. Evaluation of antioxidant properties of silymarin and its potential to inhibit peroxyl radicals in vitro. Pak J Pharm Sci. 2008 Jul;21(3):249-54. 2). Tamayo C, Diamond S. (2007). Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum Gaertn.). Integrative Cancer Therapies. 3). Joi A. Nichols, Santosh K. Katiyar (2010). Skin photoprotection by natural polyphenols: Anti-inflammatory, anti-oxidant and DNA repair mechanism). Joi A. Nichols, Santosh K. Katiyar (2010). Skin photoprotection by natural polyphenols: Anti-inflammatory, anti-oxidant and DNA repair mechanisms 4.) Gaby, Alan R. (2006). The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions. 5.) Varzi HN, Esmailzadeh S., Morowati H. Effect of silymarin and vitamin E on gentamicin-induced nephrotoxicity in dogs. (2007). Journal of Veterinary P5. Varzi HN, Esmailzadeh S., Morowati H. Effect of silymarin and vitamin E on gentamicin-induced nephrotoxicity in dogs. (2007). Journal of Veterinary Pharmacology and Therapeutics. 477-481. *Always consult your vet before giving dogs new supplements\u003c\/p\u003e","brand":"Lignans","offers":[{"title":"Default Title","offer_id":45554611781914,"sku":"20031","price":31.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/0362\/8570\/files\/30Beef-GalleryImage1_dc86eba4-2401-4b28-a67d-7e59c065a56d.jpg?v=1729436066"},{"product_id":"hmr-multi-formula-20mg-capsules","title":"HMR Multi-Formula 20mg Capsules","description":"\u003ch2\u003e\u003cstrong\u003eK9 Select Multi-Formula (HMR Lignans, Melatonin, Milk Thistle) 20mg, 90 Capsules\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003eEach bottle contains 90 unflavored capsules for dogs. Three products combined into one capsule with minimum ingredients. 90 servings of:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHMR Lignans 20 mg\u003c\/li\u003e\n\u003cli\u003eMelatonin 2 mg\u003c\/li\u003e\n\u003cli\u003eMilk Thistle 40 mg\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eWe are proud to introduce our new combination HMR products!\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eOur K9 Select HMR Multi-Formula supplements are carefully formulated for dogs to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eProvide natural hormone support *\u003c\/li\u003e\n\u003cli\u003eHelp balance estrogen, cortisol and testosterone *\u003c\/li\u003e\n\u003cli\u003ePromote a healthy immune system *\u003c\/li\u003e\n\u003cli\u003ePromote relaxation, calm and comfort *\u003c\/li\u003e\n\u003cli\u003eSupport overall health – promote normal thirst and urination *\u003c\/li\u003e\n\u003cli\u003eDaily use promotes normal skin and coat health *\u003c\/li\u003e\n\u003cli\u003eProvide natural liver support *\u003c\/li\u003e\n\u003cli\u003eProvide natural antioxidants *\u003c\/li\u003e\n\u003cli\u003eBottled in the USA\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe first active ingredient is HMR lignans. Like our Lignans for Life HMR lignans, our K9 Select lignans are sourced from the same Norwegian spruce tree knots. HMR is short for hydroxymatairesinol, which is metabolized in the body into a powerful antioxidant that prevents or limits oxidative stress throughout the body and supports the immune system. Many studies indicate that high amounts of lignans in the body may reduce cortisol and other hormone levels and promote healthy reproductive organs. * The second active ingredient is melatonin. Supplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and anxiety. * The third active ingredient is milk thistle, standardized to 80% Silymarin. Research suggests that Silymarin (the flavolignans removed from milk thistle) and its antioxidant properties can be beneficial for dogs (5). Studies also suggest that milk thistle may support a healthy liver in dogs. Milk Thistle can be beneficial for dogs with Cushings Disease (a common adrenal disorder), as liver problems are often associated with the disease due to the stress it places on the liver.\u003c\/p\u003e\n\u003ch3\u003eOther HMR Multi-Formula options:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eHMR Multi-Formula 30mg beef and cheddar chewable tablets for \u003cstrong\u003elarge dogs\u003c\/strong\u003e: \u003ca href=\"https:\/\/www.lignans.net\/product\/hmr-multi-formula-30mg-beef\/\"\u003ehttps:\/\/www.lignans.net\/product\/hmr-multi-formula-30mg-beef\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eHMR Multi-Formula 10mg peanut butter chewable tablets for \u003cstrong\u003esmall dogs\u003c\/strong\u003e: \u003ca href=\"https:\/\/www.lignans.net\/product\/hmr-multi-formula-10mg-peanut-butter\/\"\u003ehttps:\/\/www.lignans.net\/product\/hmr-multi-formula-10mg-peanut-butter\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eLignans Health Benefits\u003c\/h2\u003e\n\u003cp\u003eLignans are excellent for balancing hormone levels in the body. Specifically, lignans have been shown to reduce cortisol and other adrenal steroids and to exert anti-estrogenic effects. Such anti-estrogenic effects include the prevention of naturally occurring hormones from binding to estrogen receptors and exerting their negative effects. Lignans provide a weaker form of estrogen. Thus, they are believed to be helpful in balancing out both estrogen deficiencies (by supplying phytoestrogens to otherwise inactive receptors) and excesses (through at least two separate mechanisms – first, by competing with much stronger estrogen for the same receptors and second, by inhibiting aromatase activity). \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4375225\/\" target=\"_blank\"\u003eFurther reading here.\u003c\/a\u003e*\u003c\/p\u003e\n\u003ch3\u003eResearch\u003c\/h3\u003e\n\u003cp\u003eLignans are converted in the body into the mammalian lignans (enterolignans) enterodiol and enterolactone. Enterolignans have been shown to be potent antioxidants. They reduce the free radicals that otherwise damage tissues, membrane lipids, nucleic acids, and proteins, and may lead to diseases or premature aging. Enterolignans also stimulate the synthesis of sex hormone binding globulin, effectively binding sex hormones and thereby reducing their circulation in the blood stream and thus their biological activity. * Some studies have indicated improved hair growth. *  \u003c\/p\u003e\n\u003ch2\u003eMelatonin Health Benefits\u003c\/h2\u003e\n\u003cp\u003eSupplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and anxiety. * Melatonin decreases sex hormone secretion, modulates aromatase activity, and inhibits cortisol production. It has also been shown in some animal models to inhibit androgen production and ovarian activity. \u003ca href=\"https:\/\/avmajournals.avma.org\/doi\/abs\/10.2460\/ajvr.72.5.675\"\u003eFurther reading here\u003c\/a\u003e. Melatonin’s anti-estrogenic properties have been extensively studied. Melatonin acts in several ways to limit estrogen production and\/or activities, including by interfering with estrogen receptor activities, down-regulating estrogen expression during transcription, reducing estrogen receptor sensitivity, and inhibiting the expression of key enzymes (like aromatase) involved in estrogen production. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0301008208000348\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.omicsonline.org\/open-access\/melatonininduced-oncostasis-mechanisms-and-clinical-relevance-2329-6771-S1-006.php?aid=68975\"\u003ehere\u003c\/a\u003e. In addition, melatonin has been shown not only to inhibit cortisol itself, but also the chemical (ACTH) that signals the adrenal gland to produce cortisol. \u003ca href=\"https:\/\/academic.oup.com\/jcem\/article\/88\/1\/450\/2846096\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21332028\"\u003ehere\u003c\/a\u003e.  * Studies have shown that melatonin can reduce symptoms of stress in canines, including refusal to eat, excessive pacing or panting, as well as whimpering and licking. Melatonin may also help reduce aggressive behavior in dogs. Because the body responds to stress by producing additional cortisol, the reduction in stress, anxiety and aggression that results from melatonin supplementation may have a secondary effect (beyond the direct effects noted above) of lowering cortisol levels. * \u003ca href=\"https:\/\/www.veterinaryplace.com\/dog-medicine\/melatonin\/\"\u003eSee the recommended treatment protocols here\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eHow Melatonin Works\u003c\/h3\u003e\n\u003cp\u003eIn humans, dogs, and other animals, melatonin plays an important role in the regulation of the sleep-wake cycle. Melatonin is naturally produced by the body in the pineal system. In healthy animals, peak production of melatonin naturally occurs after sunset. Melatonin signals to the body both time of day and season (length of night). However natural production decreases as we and our pets age. This is one reason older people and pets find it difficult to get quality sleep or to sleep for as many hours as when we were younger. Melatonin may also help anxious dogs by reducing stress hormone levels. * For this use, give 1 serving melatonin products 30 minutes before stressful event. \u003ca href=\"https:\/\/www.lignans.net\/product-category\/dogs\/melatonin-dogs\/\"\u003eSee a full list of canine melatonin products here\u003c\/a\u003e. \u003cstrong\u003eNote:\u003c\/strong\u003e Always consult your physician or veterinarian before taking melatonin for yourself or for your dog. For treatment of dogs, you should not use a rapid release melatonin or a timed-release melatonin. Use only regular melatonin. All of our melatonin products fit these criteria.  \u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eMilk Thistle Health Benefits \u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eMilk Thistle is found in Europe, the Middle East and North Africa. Milk Thistle belongs to the daisy family and has been used for protection of the liver for thousands of years. Silymarin, a component of milk thistle seeds, or milk thistle extract, is a flavonoid that provides antioxidants naturally. Milk Thistle has been studied for its antioxidant properties that may support the liver(1). Other reported benefits of silymarin and milk thistle include their anti-inflammatory properties, which may support cell structure. Studies also imply that the active ingredients in milk thistle may support skin health Research suggests that Silymarin (the flavolignans removed from milk thistle) and its antioxidant properties can be beneficial for dogs (5). Studies also suggest that milk thistle may support a healthy liver in dogs. Milk Thistle can be beneficial for dogs with Cushings Disease (a common adrenal disorder), as liver problems are often associated with the disease due to the stress it places on the liver.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eMilk Thistle Side Effects\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eVery few side effects have been reported after using milk thistle. In rare cases, it may have a laxative effect, but such instances are uncommon. It is always important to consult your doctor or physician before starting any new supplement. \u003cb\u003eNote: \u003c\/b\u003eAn additional product to consider is SAMe for liver support. Milk Thistle and SAMe are often used together for added benefits. \u003ca href=\"https:\/\/www.lignans.net\/k9-same.html\"\u003eClick here to read about SAMe for dogs\u003c\/a\u003e  \u003c\/p\u003e\n\u003ch2\u003eGeneral Dosages \u0026amp; Directions\u003c\/h2\u003e\n\u003cp\u003eFor adult dogs, give 1 capsule for every 20 lbs of body weight. Capsule can be administered whole as a treat or hidden in food. It can also be opened and the powder can be mixed into a small amount of peanut butter, a small piece of cheese, a pill pocket, etc. A second serving of melatonin is recommended later in the day, as noted below. \u003cstrong\u003eImportant Note\u003c\/strong\u003e: Lignans and Milk Thistle are recommended once per day. Melatonin is recommended every 12 hours, so a second serving of melatonin should be given 12 hours after the Multi-Formula tablet, as follows:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e6 mg of melatonin for dogs over 30 lbs.\u003c\/li\u003e\n\u003cli\u003e3 mg of melatonin for dogs under 30 lbs.\u003c\/li\u003e\n\u003cli\u003e1 mg of melatonin may be recommended for dogs 10 lbs. or less, or for those who want to give their dogs very low doses of melatonin.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.lignans.net\/product-category\/dogs\/melatonin-dogs\/\"\u003eSee a full list of canine melatonin products here\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e(Click the following link for more detailed info on \u003ca href=\"https:\/\/www.lignans.net\/lignans-dosage-for-dogs.html\" target=\"_blank\"\u003eLignans Dosage for Dogs.\u003c\/a\u003e Click the following link for more detailed info on \u003ca href=\"https:\/\/www.lignans.net\/melatonin-dosage-for-dogs\"\u003eMelatonin Dosages for Dogs\u003c\/a\u003e. Recommended milk thistle dosage for healthy dogs is approximately 2 mg of milk thistle for each pound of dog's weight.) \u003cb\u003eNote:\u003c\/b\u003e Always consult your veterinarian when trying new supplements.     \u003cb\u003eResearch\u003c\/b\u003e 1). Asghar Z, Masood Z. Evaluation of antioxidant properties of silymarin and its potential to inhibit peroxyl radicals in vitro. Pak J Pharm Sci. 2008 Jul;21(3):249-54. 2). Tamayo C, Diamond S. (2007). Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum Gaertn.). Integrative Cancer Therapies. 3). Joi A. Nichols, Santosh K. Katiyar (2010). Skin photoprotection by natural polyphenols: Anti-inflammatory, anti-oxidant and DNA repair mechanism). Joi A. Nichols, Santosh K. Katiyar (2010). Skin photoprotection by natural polyphenols: Anti-inflammatory, anti-oxidant and DNA repair mechanisms 4.) Gaby, Alan R. (2006). The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions. 5.) Varzi HN, Esmailzadeh S., Morowati H. Effect of silymarin and vitamin E on gentamicin-induced nephrotoxicity in dogs. (2007). Journal of Veterinary P5. Varzi HN, Esmailzadeh S., Morowati H. Effect of silymarin and vitamin E on gentamicin-induced nephrotoxicity in dogs. (2007). Journal of Veterinary Pharmacology and Therapeutics. 477-481. *Always consult your vet before giving dogs new supplements\u003c\/p\u003e","brand":"Lignans","offers":[{"title":"Default Title","offer_id":45554611847450,"sku":"20032","price":27.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/0362\/8570\/files\/20Unflavored-GalleryImage1.jpg?v=1729436010"},{"product_id":"hmr-multi-formula-10mg-peanut-butter","title":"HMR Multi-Formula 10mg Tablets Peanut Butter Flavored","description":"\u003ch2\u003e\u003cstrong\u003eK9 Select Multi-Formula (HMR Lignans, Melatonin, Milk Thistle) 10mg, 90 Tablets\u003c\/strong\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003ePeanut Butter Flavored\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eEach bottle contains\u003cstrong\u003e 90 peanut butter flavored tablets\u003c\/strong\u003e for dogs. Three products combined into one flavored tablet for 90 servings of:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHMR Lignans 10 mg\u003c\/li\u003e\n\u003cli\u003eMelatonin 1 mg\u003c\/li\u003e\n\u003cli\u003eMilk Thistle 20 mg\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cb\u003eWe are proud to introduce our new combination HMR products!\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eTasty peanut butter flavored tablets that your dog will love! Our K9 Select HMR Multi-Formula supplements are carefully formulated for dogs to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eProvides natural hormone support *\u003c\/li\u003e\n\u003cli\u003eHelp balance estrogen, cortisol and testosterone *\u003c\/li\u003e\n\u003cli\u003ePromote a healthy immune system *\u003c\/li\u003e\n\u003cli\u003ePromote relaxation, calm and comfort *\u003c\/li\u003e\n\u003cli\u003eSupport overall health – promotes normal thirst and urination *\u003c\/li\u003e\n\u003cli\u003eDaily use promotes normal skin and coat health *\u003c\/li\u003e\n\u003cli\u003eProvide natural liver support *\u003c\/li\u003e\n\u003cli\u003eProvide natural antioxidants *\u003c\/li\u003e\n\u003cli\u003eBottled in the USA\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe first active ingredient is HMR lignans. Like our Lignans for Life HMR lignans, our K9 Select lignans are sourced from the same Norwegian spruce tree knots. HMR is short for hydroxymatairesinol, which is metabolized in the body into a powerful antioxidant that prevents or limits oxidative stress throughout the body and supports the immune system. Many studies indicate that high amounts of lignans in the body may reduce cortisol and other hormone levels and promote healthy reproductive organs. * The second active ingredient is melatonin. Supplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and anxiety. * The third active ingredient is milk thistle, standardized to 80% Silymarin. Research suggests that Silymarin (the flavolignans removed from milk thistle) and its antioxidant properties can be beneficial for dogs (5). Studies also suggest that milk thistle may support a healthy liver in dogs. Milk Thistle can be beneficial for dogs with Cushings Disease (a common adrenal disorder), as liver problems are often associated with the disease due to the stress it places on the liver.\u003c\/p\u003e\n\u003ch3\u003eOther HMR Multi-Formula options:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eHMR Multi-Formula 30mg beef and cheddar chewable tablets for \u003cstrong\u003elarge dogs\u003c\/strong\u003e: \u003ca href=\"https:\/\/www.lignans.net\/product\/hmr-multi-formula-30mg-beef\/\"\u003ehttps:\/\/www.lignans.net\/product\/hmr-multi-formula-30mg-beef\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eHMR Multi-Formula 20mg unflavored capsules for \u003cstrong\u003emedium dogs\u003c\/strong\u003e: \u003ca href=\"https:\/\/www.lignans.net\/product\/hmr-multi-formula-20mg-capsules\/\"\u003ehttps:\/\/www.lignans.net\/product\/hmr-multi-formula-20mg-capsules\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eLignans Health Benefits\u003c\/h2\u003e\n\u003cp\u003eLignans are excellent for balancing hormone levels in the body. Specifically, lignans have been shown to reduce cortisol and other adrenal steroids and to exert anti-estrogenic effects. Such anti-estrogenic effects include the prevention of naturally occurring hormones from binding to estrogen receptors and exerting their negative effects. Lignans provide a weaker form of estrogen. Thus, they are believed to be helpful in balancing out both estrogen deficiencies (by supplying phytoestrogens to otherwise inactive receptors) and excesses (through at least two separate mechanisms – first, by competing with much stronger estrogen for the same receptors and second, by inhibiting aromatase activity). \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0301008208000348\" target=\"_blank\" rel=\"noopener\"\u003eFurther reading here.\u003c\/a\u003e*\u003c\/p\u003e\n\u003ch3\u003eResearch\u003c\/h3\u003e\n\u003cp\u003eLignans are converted in the body into the mammalian lignans (enterolignans) enterodiol and enterolactone. Enterolignans have been shown to be potent antioxidants. They reduce the free radicals that otherwise damage tissues, membrane lipids, nucleic acids, and proteins, and may lead to diseases or premature aging. Enterolignans also stimulate the synthesis of sex hormone binding globulin, effectively binding sex hormones and thereby reducing their circulation in the blood stream and thus their biological activity. * Some studies have indicated improved hair growth. *  \u003c\/p\u003e\n\u003ch2\u003eMelatonin Health Benefits\u003c\/h2\u003e\n\u003cp\u003eSupplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and anxiety. * Melatonin decreases sex hormone secretion, modulates aromatase activity, and inhibits cortisol production. It has also been shown in some animal models to inhibit androgen production and ovarian activity. \u003ca href=\"https:\/\/avmajournals.avma.org\/doi\/abs\/10.2460\/ajvr.72.5.675\"\u003eFurther reading here\u003c\/a\u003e. Melatonin’s anti-estrogenic properties have been extensively studied. Melatonin acts in several ways to limit estrogen production and\/or activities, including by interfering with estrogen receptor activities, down-regulating estrogen expression during transcription, reducing estrogen receptor sensitivity, and inhibiting the expression of key enzymes (like aromatase) involved in estrogen production. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0301008208000348\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.omicsonline.org\/open-access\/melatonininduced-oncostasis-mechanisms-and-clinical-relevance-2329-6771-S1-006.php?aid=68975\"\u003ehere\u003c\/a\u003e. In addition, melatonin has been shown not only to inhibit cortisol itself, but also the chemical (ACTH) that signals the adrenal gland to produce cortisol. \u003ca href=\"https:\/\/academic.oup.com\/jcem\/article\/88\/1\/450\/2846096\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21332028\"\u003ehere\u003c\/a\u003e.  * Studies have shown that melatonin can reduce symptoms of stress in canines, including refusal to eat, excessive pacing or panting, as well as whimpering and licking. Melatonin may also help reduce aggressive behavior in dogs. Because the body responds to stress by producing additional cortisol, the reduction in stress, anxiety and aggression that results from melatonin supplementation may have a secondary effect (beyond the direct effects noted above) of lowering cortisol levels. * \u003ca href=\"https:\/\/www.veterinaryplace.com\/dog-medicine\/melatonin\/\"\u003eSee the recommended treatment protocols here\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eHow Melatonin Works\u003c\/h3\u003e\n\u003cp\u003eIn humans, dogs, and other animals, melatonin plays an important role in the regulation of the sleep-wake cycle. Melatonin is naturally produced by the body in the pineal system. In healthy animals, peak production of melatonin naturally occurs after sunset. Melatonin signals to the body both time of day and season (length of night). However natural production decreases as we and our pets age. This is one reason older people and pets find it difficult to get quality sleep or to sleep for as many hours as when we were younger. Melatonin may also help anxious dogs by reducing stress hormone levels. * For this use, give 1 serving melatonin products 30 minutes before stressful event. \u003ca href=\"https:\/\/www.lignans.net\/product-category\/dogs\/melatonin-dogs\/\"\u003eSee a full list of canine melatonin products here\u003c\/a\u003e. \u003cstrong\u003eNote:\u003c\/strong\u003e Always consult your physician or veterinarian before taking melatonin for yourself or for your dog. For treatment of dogs, you should not use a rapid release melatonin or a timed-release melatonin. Use only regular melatonin. All of our melatonin products fit these criteria.  \u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eMilk Thistle Health Benefits \u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eMilk Thistle is found in Europe, the Middle East and North Africa. Milk Thistle belongs to the daisy family and has been used for protection of the liver for thousands of years. Silymarin, a component of milk thistle seeds, or milk thistle extract, is a flavonoid that provides antioxidants naturally. Milk Thistle has been studied for its antioxidant properties that may support the liver(1). Other reported benefits of silymarin and milk thistle include their anti-inflammatory properties, which may support cell structure. Studies also imply that the active ingredients in milk thistle may support skin health Research suggests that Silymarin (the flavolignans removed from milk thistle) and its antioxidant properties can be beneficial for dogs (5). Studies also suggest that milk thistle may support a healthy liver in dogs. Milk Thistle can be beneficial for dogs with Cushings Disease (a common adrenal disorder), as liver problems are often associated with the disease due to the stress it places on the liver.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eMilk Thistle Side Effects\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eVery few side effects have been reported after using milk thistle. In rare cases, it may have a laxative effect, but such instances are uncommon. It is always important to consult your doctor or physician before starting any new supplement. \u003cb\u003eNote: \u003c\/b\u003eAn additional product to consider is SAMe for liver support. Milk Thistle and SAMe are often used together for added benefits. \u003ca href=\"https:\/\/www.lignans.net\/k9-same.html\"\u003eClick here to read about SAMe for dogs\u003c\/a\u003e  \u003c\/p\u003e\n\u003ch2\u003eGeneral Dosages \u0026amp; Directions\u003c\/h2\u003e\n\u003cp\u003eFor adult dogs, give 1 chewable tablet for every 10 lbs of body weight. Tablet can be administered whole as a treat or hidden in food. It can also be given with a small amount of peanut butter, a small piece of cheese, a pill pocket, etc. A second serving of melatonin is recommended later in the day, as noted below. \u003cstrong\u003eImportant Note\u003c\/strong\u003e: Lignans and Milk Thistle are recommended once per day. Melatonin is recommended every 12 hours, so a second serving of melatonin should be given 12 hours after the Multi-Formula tablet, as follows:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e1 mg of melatonin may be recommended for dogs 10 lbs. or less, or for those who want to give their dogs very low doses of melatonin.\u003c\/li\u003e\n\u003cli\u003e3 mg of melatonin for dogs under 30 lbs.\u003c\/li\u003e\n\u003cli\u003e6 mg of melatonin for dogs over 30 lbs.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.lignans.net\/product-category\/dogs\/melatonin-dogs\/\"\u003eSee a full list of canine melatonin products here\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e(Click the following link for more detailed info on \u003ca href=\"https:\/\/www.lignans.net\/lignans-dosage-for-dogs.html\" target=\"_blank\"\u003eLignans Dosage for Dogs.\u003c\/a\u003e Click the following link for more detailed info on \u003ca href=\"https:\/\/www.lignans.net\/melatonin-dosage-for-dogs\"\u003eMelatonin Dosages for Dogs\u003c\/a\u003e. Recommended milk thistle dosage for healthy dogs is approximately 2 mg of milk thistle for each pound of dog's weight.) \u003cb\u003eNote:\u003c\/b\u003e Always consult your veterinarian when trying new supplements.     \u003cb\u003eResearch\u003c\/b\u003e 1). Asghar Z, Masood Z. Evaluation of antioxidant properties of silymarin and its potential to inhibit peroxyl radicals in vitro. Pak J Pharm Sci. 2008 Jul;21(3):249-54. 2). Tamayo C, Diamond S. (2007). Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum Gaertn.). Integrative Cancer Therapies. 3). Joi A. Nichols, Santosh K. Katiyar (2010). Skin photoprotection by natural polyphenols: Anti-inflammatory, anti-oxidant and DNA repair mechanism). Joi A. Nichols, Santosh K. Katiyar (2010). Skin photoprotection by natural polyphenols: Anti-inflammatory, anti-oxidant and DNA repair mechanisms 4.) Gaby, Alan R. (2006). The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions. 5.) Varzi HN, Esmailzadeh S., Morowati H. Effect of silymarin and vitamin E on gentamicin-induced nephrotoxicity in dogs. (2007). Journal of Veterinary P5. Varzi HN, Esmailzadeh S., Morowati H. Effect of silymarin and vitamin E on gentamicin-induced nephrotoxicity in dogs. (2007). Journal of Veterinary Pharmacology and Therapeutics. 477-481. *Always consult your vet before giving dogs new supplements\u003c\/p\u003e","brand":"Lignans","offers":[{"title":"Default Title","offer_id":45554611912986,"sku":"20033","price":21.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/0362\/8570\/files\/10PeanutButter-GalleryImage1.jpg?v=1729435882"},{"product_id":"6mg-peanut-butter-melatonin-for-dogs","title":"K9 Select 6MG Peanut Butter Melatonin for Dogs","description":"\u003ch1\u003eK9 Select Melatonin 6 mg For Dogs: Peanut Butter Flavored Chewable Tablet\u003c\/h1\u003e\n\u003cp\u003e120 tablets. 120 servings of 6 mg. Each bottle contains 120 tablets of 6 mg peanut butter flavored \u003ca href=\"https:\/\/www.lignans.net\/product-category\/dogs\/melatonin-dogs\/\"\u003emelatonin for dogs\u003c\/a\u003e. Our K9 Select brand melatonin supplements for dogs are carefully formulated to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePromote a natural sleep-wake cycle *\u003c\/li\u003e\n\u003cli\u003eProvide natural hormone support *\u003c\/li\u003e\n\u003cli\u003ePromote relaxation, calm and comfort *\u003c\/li\u003e\n\u003cli\u003eSupport overall health – promote normal thirst and urination *\u003c\/li\u003e\n\u003cli\u003eDaily use promotes normal skin and coat health *\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow Melatonin Works\u003c\/h3\u003e\n\u003cp\u003eIn humans, dogs, and other animals, melatonin plays an important role in the regulation of the sleep-wake cycle. Melatonin is naturally produced by the body in the pineal system. In healthy animals, peak production of melatonin naturally occurs after sunset. Melatonin signals to the body both time of day and season (length of night). However natural production decreases as we and our pets age. This is one reason older people and pets find it difficult to get quality sleep or to sleep for as many hours as when we were younger.\u003c\/p\u003e\n\u003ch3\u003eMelatonin Health Benefits\u003c\/h3\u003e\n\u003cp\u003eSupplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and anxiety. * Melatonin decreases sex hormone secretion, modulates aromatase activity, and inhibits cortisol production. It has also been shown in some animal models to inhibit androgen production and ovarian activity. \u003ca href=\"https:\/\/avmajournals.avma.org\/doi\/abs\/10.2460\/ajvr.72.5.675\"\u003eFurther reading here\u003c\/a\u003e. Melatonin’s anti-estrogenic properties have been extensively studied. Melatonin acts in several ways to limit estrogen production and\/or activities, including by interfering with estrogen receptor activities, down-regulating estrogen expression during transcription, reducing estrogen receptor sensitivity, and inhibiting the expression of key enzymes (like aromatase) involved in estrogen production. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0301008208000348\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.omicsonline.org\/open-access\/melatonininduced-oncostasis-mechanisms-and-clinical-relevance-2329-6771-S1-006.php?aid=68975\"\u003ehere\u003c\/a\u003e. In addition, melatonin has been shown not only to inhibit cortisol itself, but also the chemical (ACTH) that signals the adrenal gland to produce cortisol. \u003ca href=\"https:\/\/academic.oup.com\/jcem\/article\/88\/1\/450\/2846096\"\u003eFurther reading here\u003c\/a\u003e and \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21332028\"\u003ehere\u003c\/a\u003e.  * Studies have shown that melatonin can reduce symptoms of stress in canines, including refusal to eat, excessive pacing or panting, as well as whimpering and licking. Melatonin may also help reduce aggressive behavior in dogs. Because the body responds to stress by producing additional cortisol, the reduction in stress, anxiety and aggression that results from melatonin supplementation may have a secondary effect (beyond the direct effects noted above) of lowering cortisol levels. * \u003cstrong\u003eNote:\u003c\/strong\u003e Always consult your physician or veterinarian before taking melatonin for yourself or for your dog. For treatment of dogs, you should not use a rapid release melatonin or a timed-release melatonin. Use only regular melatonin. All of our melatonin products fit these criteria. \u003ca href=\"https:\/\/www.veterinaryplace.com\/dog-medicine\/melatonin\/\"\u003eSee the recommended treatment protocols here\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eDirections for Dogs\u003c\/h3\u003e\n\u003cp\u003eThe University of Tennessee College of Veterinary Medicine recommends, and the late Dr. Jack Oliver, DVM, former Chairman of UofT's Veterinary Endocrinology Department, recommended:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e6 mg of melatonin (1 tablet) every 12 hours for dogs over 30 lbs.\u003c\/li\u003e\n\u003cli\u003e3 mg of melatonin (1\/2 tablet) every 12 hours for dogs under 30 lbs.\u003c\/li\u003e\n\u003cli\u003e1 mg of melatonin (see our \u003ca href=\"https:\/\/www.lignans.net\/product\/k9-select-chewable-1-mg-melatonin-for-dogs-beef-flavor-180-tabs\/\"\u003e1 mg tablet\u003c\/a\u003e) every 12 hours may be recommended for dogs 10 lbs. or less, or for those who want to give their dogs very low doses of melatonin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.lignans.net\/melatonin-dosage-for-dogs\"\u003eRecommended dosages for dogs\u003c\/a\u003e. Melatonin may also help anxious dogs by reducing stress hormone levels. * For this use, give 1 serving 30 minutes before stressful event.\u003c\/p\u003e","brand":"Lignans","offers":[{"title":"Default Title","offer_id":45554612109594,"sku":"20039","price":20.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/0362\/8570\/files\/6mgPeanut-GalleryImage1.jpg?v=1733488560"},{"product_id":"k9-select-calming-soft-chews","title":"K9 Select Calming Soft Chews for Dogs – Peanut Butter │ Melatonin Treats for Relaxation \u0026 Anxiety (120 Chews)","description":"\u003ch2\u003eHelp your dog find their calm\u003c\/h2\u003e\n\u003cp\u003eK9 Select Calming Soft Chews blend soothing botanicals with 1 mg of melatonin in an irresistible peanut butter treat — a gentle, non-drowsy way to help your dog relax and settle down when life gets stressful. From thunderstorms to travel to everyday hyperactivity, one tasty chew helps take the edge off.\u003c\/p\u003e\n\n\u003ch3\u003eCalm for life’s stressful moments\u003c\/h3\u003e\n\u003cul\u003e\n  \u003cli\u003eThunderstorms \u0026amp; fireworks\u003c\/li\u003e\n  \u003cli\u003eTravel \u0026amp; car rides\u003c\/li\u003e\n  \u003cli\u003eSeparation \u0026amp; time alone\u003c\/li\u003e\n  \u003cli\u003eVet visits \u0026amp; grooming\u003c\/li\u003e\n  \u003cli\u003eEveryday hyperactivity \u0026amp; restlessness\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003ePowered by a calming blend\u003c\/h3\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003eL-Theanine (50 mg)\u003c\/strong\u003e — promotes relaxation without the grogginess\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eChamomile (30 mg)\u003c\/strong\u003e — a time-honored soothing herb\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003ePassionflower (25 mg)\u003c\/strong\u003e — supports a calm, balanced mood\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eValerian Root (22 mg)\u003c\/strong\u003e — helps ease tension\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eL-Tryptophan (17 mg)\u003c\/strong\u003e — supports healthy serotonin levels\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eGinger (14 mg)\u003c\/strong\u003e — settles the stomach for smoother car rides\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eMelatonin (1 mg)\u003c\/strong\u003e — supports restful, natural relaxation\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eNon-sedating and made with a peanut butter flavor dogs love — no pills to hide. Proudly manufactured in the USA in an SQF-certified, FDA-registered facility.\u003c\/p\u003e\n\n\u003ch3\u003eDirections\u003c\/h3\u003e\n\u003cp\u003eFor dogs over 12 weeks: give 1 soft chew per 10 lbs of body weight, one to two times per day, with at least 12 hours between doses. For situational stress, offer 30–60 minutes before the triggering event.\u003c\/p\u003e\n\n\u003ch3\u003eGuaranteed Analysis \u003cspan\u003e(per 2.2 g chew)\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003cp\u003eL-Theanine 50 mg • Chamomile Powder 30 mg • Passionflower Powder 25 mg • Valerian Root Powder 22 mg • L-Tryptophan 17 mg • Ginger 14 mg • Melatonin 1 mg\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eNet wt. 9.3 oz (264 g) • 120 soft chews. Manufactured in a SQF-certified, FDA-registered facility for Lignans for Life, Hopkinton MA.\u003c\/em\u003e\u003c\/p\u003e\n","brand":"Lignans for Life","offers":[{"title":"Default Title","offer_id":52517492883738,"sku":"20045","price":23.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/0362\/8570\/files\/MelatoninSoftChew1mgMAIN1024white.png?v=1784198167"}],"url":"https:\/\/lignans.com\/collections\/melatonin-dogs.oembed?page=2","provider":"Lignans for Life","version":"1.0","type":"link"}